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MDToolbox

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MDToolbox-Rx is a standalone, cloud-based e-prescribing system for independent prescribers, with optional EPCS for Schedule II-V drugs. Plans are priced per prescriber with published monthly rates, free staff users, mobile apps, and a 30-day free trial without a credit card.

From $28/prescriber/mo (billed annually)

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Our take on MDToolbox

MDToolbox-Rx is a standalone, web-based e-prescribing system with published per-prescriber pricing of $28 to $38 a month, EPCS on the Complete plan and free mobile apps. It suits independent and telehealth prescribers who do not have e-prescribing in their EHR. The trade-off is that it is a single-purpose tool, and two-way data sync with other software costs extra.

Also known as: MDToolbox-Rx, MDToolbox e-Prescribing, MDToolbox EPCS, MDToolbox Smart e-PA, MDToolbox-Direct · Reviewed by PracticeAll's healthcare IT team · Facts last verified · How we review

MDToolbox key facts

Best for
Independent prescribers who need low-cost standalone e-prescribing and EPCS
Practice size
solo, small_group
Specialties
Multi-specialty, Telemedicine
Starting price
From $28/prescriber/mo (billed annually)
Pricing model
Per prescriber/month
Deployment
Cloud, iOS, Android
HIPAA / BAA
Not stated by vendor
Integrations
HL7 interface, CCD and patient API data sync, state PMP integrations, Surescripts network
Company
MDToolbox
Category
e-Prescribing (eRx) & Pharmacy
Last verified
October 2026

MDToolbox feature checklist

EPCS CertifiedYes
Clinical Decision SupportDrug-Drug Interaction Alerts
Medication History PullYes

Who MDToolbox is best for

MDToolbox-Rx is for prescribers who need to send prescriptions electronically without buying a full EHR: solo clinicians, telemedicine providers and groups whose EHR lacks EPCS. It is a Surescripts-certified e-prescribing provider, its EPCS function has been audited by a qualified DEA auditor, and its Rx module is ONC-certified.

Best for

  • Solo and small practices that want e-prescribing for about $30 a month per prescriber
  • Telehealth and psychiatry prescribers who need EPCS for Schedule II–V drugs
  • Practices that want to keep their current EHR and add a separate prescribing tool

Not ideal for

  • Practices that want prescribing inside their charting and billing system

MDToolbox pros and cons

Pros

  • Published pricing: $28 per month annual, $30 monthly; EPCS plan $35 annual, $38 monthly
  • 30-day free trial with real prescriptions and no credit card
  • No long-term contract required; monthly plans can be cancelled anytime
  • Free iPhone, iPad and Android apps with every subscription
  • Real-time prescription benefit and pricing, formulary checks, state PMP lookups and electronic prior authorization
  • Up to 10 staff users per prescriber at no charge

Cons

  • Prescribing only; no charting, scheduling or billing
  • Two-way data sync carries a $700 one-time setup fee plus $30 to $50 a month
  • Secure Direct messaging and visit notes are paid add-ons
  • The vendor publishes little company background, such as location or founding year

MDToolbox pricing

MDToolbox publishes its prices (per prescriber):

  • E-Prescribe Pro: $28 per month billed annually ($336 per year) or $30 month-to-month; non-controlled prescribing.
  • E-Prescribe Complete: $35 per month billed annually ($420 per year) or $38 month-to-month; adds EPCS.

Staff users are free up to 10 per prescriber, then $3 per user per month. Add-ons include Visit Notes ($10 per provider per month) and Secure Messaging ($10 per address per month, or $120 a year, plus a $50 setup fee per address). Manual uploads and one-way HL7 sync are free; two-way HL7 or CCD sync is $30 a month and a two-way patient API is $50 a month, each with a $700 one-time setup fee and 1,000 syncs a month included.

Key features

  • e-Prescribing Software (MDToolbox-Rx): favorites lists, SIG builder, one-click refills, electronic refill requests and cancels
  • EPCS: Schedule II–V prescribing with two-factor sign-off, on the Complete plan
  • e-Rx Mobile: prescribing from iPhone, iPad and Android devices
  • Smart e-PA: electronic prior authorization at the point of prescribing, with prefilled smart forms
  • Rx Pricing: real-time benefit and pharmacy pricing, included with standalone subscriptions
  • Clinical tools: drug-allergy, drug-drug and other customizable alerts, a dosing calculator, and allergy and problem list tracking
  • State PMP integrations from within the prescription writer
  • Direct Messaging: secure health information exchange, as an add-on

HIPAA, security and integrations

MDToolbox describes the system as HIPAA compliant with PHI encrypted. Its Rx module is certified to the ONC 2015 Edition criteria (CHPL product number 15.02.05.1832.MDTB.01.01.1.211105, last certified November 5, 2021) and it publishes ONC Real World Testing plans and results. EPCS sign-off uses two-factor authentication, as the DEA requires. It routes prescriptions over the Surescripts network, which the vendor says reaches 99% of US pharmacies. SOC 2 or HITRUST status and BAA terms are not published.

The system can share patient lists with practice management or EHR software through HL7 or CCD messages, an API and patient importers; MDToolbox also offers an API for embedding its prescribing inside another EHR.

MDToolbox alternatives

  • DrFirst — e-prescribing and medication management with broad EHR partnerships and enterprise options.
  • DoseSpot — e-prescribing designed to be embedded in other vendors' software, popular with telehealth platforms.
  • RXNT eRx — standalone e-prescribing that can grow into RXNT's EHR and billing suite.
  • Ensora eRx (formerly NewCrop) — e-prescribing module used inside many EHR and PM systems.

More e-Prescribing (eRx) & Pharmacy Software

Comparing options? See every product side by side in our e-Prescribing (eRx) & Pharmacy software guide.

MDToolbox FAQ

Is MDToolbox good for small practices?

Yes. MDToolbox-Rx is aimed at small and medium practices that need e-prescribing without a full EHR. Pricing is per prescriber with no long-term contract, and the 30-day trial lets you send real prescriptions.

How much does MDToolbox cost?

E-Prescribe Pro costs $28 per prescriber per month on an annual plan or $30 month-to-month. E-Prescribe Complete, which adds controlled substances, costs $35 per month annually or $38 monthly. Visit notes, Direct messaging and two-way data sync cost extra.

Does MDToolbox support EPCS for controlled substances?

Yes. The E-Prescribe Complete plan supports electronic prescribing of Schedule II through V controlled substances, with two-factor authentication at sign-off, using the same workflow as other prescriptions. The Pro plan covers non-controlled prescriptions only.

Is MDToolbox HIPAA compliant and ONC certified?

MDToolbox states that the system is HIPAA compliant and that PHI is encrypted. Its Rx module is ONC-certified to the 2015 Edition criteria and listed on CHPL. It does not publish SOC 2 status or BAA terms, so ask about a BAA before signing up.

Does MDToolbox integrate with my EHR?

It can exchange patient data with EHR and practice management systems. Manual uploads and one-way HL7 sync are free, while two-way HL7, CCD or API sync costs a $700 one-time setup fee plus $30 to $50 a month. Prescribers work in the MDToolbox screen rather than inside the EHR.

MDToolbox vs DoseSpot: which should I choose?

MDToolbox suits an individual prescriber or practice that wants a ready-to-use standalone tool with published monthly pricing and its own mobile apps. DoseSpot is built to be embedded inside other software platforms rather than used as a separate screen. If you are a clinician buying for yourself, MDToolbox is the more direct fit.

Sources

Facts on this page were checked against these sources on October 2026.

  1. MDToolbox pricing
  2. MDToolbox homepage
  3. MDToolbox stand-alone e-prescribing overview
  4. MDToolbox ONC certification
  5. MDToolbox Smart e-PA
  6. MDToolbox EPCS
  7. About MDToolbox

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The information on this page may be outdated or inaccurate. PracticeAll does not guarantee the validity of this information. Please verify details directly with the software vendor before making purchasing decisions.